Genomic variants-driven drug repurposing for tuberculosis by utilizing the established bioinformatic-based approachShort communication Published on 2022-12-012022-10-05 Journal: Biochemistry and Biophysics Reports [Category] 신약개발, [키워드] annotations applied approach bioinformatics biological process CCR5 CD44 cellular component contribute CXCR4 demonstrated deregulation disease disease-associated drug Drug discovery Drug repurposing drug target evaluated Evidence facilitate functional functional annotation Genes genomic genomic variant genomic variants GWAS HLA-B identify implementation in-silico indication involved KEGG Missense mutation molecular overlapped Pathogenesis Pathway analysis provided risk SELP suggested target Treatment Tuberculosis variant [DOI] 10.1016/j.bbrep.2022.101334 [Article Type] Short communication
Dynamics of competing SARS-CoV-2 variants during the Omicron epidemic in England영국의 오미크론 전염병 동안 경쟁하는 SARS-CoV-2 변이체의 역학Article Published on 2022-07-282022-09-11 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] assessment competing cross-sectional survey Cross-sectional surveys Dynamics England Epidemic Epidemics estimate evade exhibited followed by genomic variants immune evasion infection rate initial Lineage magnitude National Neutralising Antibodies omicron Omicron variant population immunity Prevalence replaced resurgence SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 neutralising antibodies SARS-CoV-2 pandemic SARS-CoV-2 variant variant variants [DOI] 10.1038/s41467-022-32096-4 PMC 바로가기 [Article Type] Article
A simple reverse genetics method to generate recombinant coronaviruses재조합 코로나바이러스를 생성하는 간단한 역유전학 방법Article Published on 2022-05-042022-09-11 Journal: EMBO Reports [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] accelerate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 advance Antiviral assays antivirals biological property Biology cDNA Characteristics Complete coronavirus coronavirus coronavirus genome coronavirus genomes Diagnosis effective Engineering facilitate fluorescent generate genetics genomic genomic variant genomic variants in vivo in vivo experiment in vivo experiments molecular Mutation Pathogens reagents reconstruction reporter reporter strain reverse genetics SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variants serological serology Serology. severe acute respiratory syndrome Coronavirus simplicity Specific specific mutations Strains the SARS-CoV-2 the SARS-CoV-2 genome therapeutic variants viral pathogen virus wild-type [DOI] 10.15252/embr.202153820 PMC 바로가기 [Article Type] Article
SARS-CoV-2 historical global testing and genomic variabilitySARS-CoV-2 과거 글로벌 테스트 및 게놈 가변성Article Published on 2022-04-012022-09-11 Journal: BMC Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] analyzed comprehensive resource country Covid19 genomic variability Covid19 testing Dashboard database dataset datasets downloaded effort genomic Genomic variability genomic variants GISAID information outbreak pandemic provide SARS-CoV-2 SARS-CoV-2 genomic sequence SARS-CoV-2 genomic sequences SARS-CoV-2 genomic variability SARS-CoV-2 pandemic SARS-CoV-2 testing SARS-CoV-2 testing. Spread submission Test statistics variants virus [DOI] 10.1186/s12879-022-07147-2 PMC 바로가기 [Article Type] Article
Healthy Immunity on Preventive Medicine for Combating COVID-19Review Published on 2022-02-272022-10-31 Journal: Nutrients [Category] COVID-19, [키워드] acute respiratory syndrome advance aging and underlying medical conditions antioxidants approaches Asymptomatic binding biological processe caused cellular structures combating complications coronavirus Coronavirus disease 2019 COVID-19 deficiency disease enzyme events Gender genomic genomic variants Health healthy help Host host cell Host–pathogen interaction immune health immune responses immune system Immunity immunomodulation include Infection Infectious disease management Medical conditions medication Medicine men micronutrients Minerals molecular morbidity Mortality multifactorial nutrition Occurrence organs outcomes Pathogenesis pathogenesis of COVID-19 Pathogens Pathologies physiological activities populations Prevent preventive measure proteomic receptors regulated SARS-CoV-2 severe symptoms Sex signaling molecules Therapeutic strategies treat unique vaccination variety vitamins with COVID-19 women [DOI] 10.3390/nu14051004 PMC 바로가기 [Article Type] Review
Classical and Next-Generation Vaccine Platforms to SARS-CoV-2: Biotechnological Strategies and Genomic VariantsSARS-CoV-2에 대한 고전 및 차세대 백신 플랫폼: 생명공학 전략 및 게놈 변이Review Published on 2022-02-182022-09-10 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, [키워드] aAPC Ad5-nCoV adaptive Amino acid amino acids animals antibody applied B.1.1.7 B1.351 BBIBP-CorV bind Biotechnology BNT Cell classical clinical trial consequence CoronaVac coronavirus COVID-19 COVID-19 vaccine COVID-19 vaccines CoVs D614G Deletion demonstrated dendritic cell dendritic cells domain escape Evolution genomic variant genomic variants HCoV HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 high affinity HKU1 hosts Human humans inactivated incorporation inhibit INO-4800 JNJ-78436735 lentiviral Lentiviral vector LV-SMENP-DC MERS-CoV molecular mRNA mRNA-1273 mutated nCoV New new SARS-CoV-2 new strain NL63 NVX-CoV2373 vaccine P.1 pathogen Pathogens platform Protein RBD receptor ACE2 Receptor-binding domain recombinant vaccine recombinant vaccines replacement residue responsible RNA vaccines S protein SARS-CoV SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variants strain Strains Strategy subunits technological platforms tested the S protein Transmissibility trials Vaccine vaccine production Vaccines variant variants variety Viral virus-like particles β-coronavirus β-CoV β-CoVs [DOI] 10.3390/ijerph19042392 PMC 바로가기 [Article Type] Review
ViralFlow: A Versatile Automated Workflow for SARS-CoV-2 Genome Assembly, Lineage Assignment, Mutations and Intrahost Variant DetectionArticle Published on 2022-01-232022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] amplicon sequencing data analysis Analysis assembly bioinformatics Clusters coronavirus COVID-19 pandemic CPU core detection driven by FIVE genome assembly genomic Genomic analysis Genomic surveillance genomic variants Genomics genotyping gold standard highlight Illumina implementation less Lineage lineages memory methodology MONITOR Mutation provided respiratory SARS-CoV-2 SARS-CoV-2 genomic data Software Spread variants virus virus bioinformatics viruses [DOI] 10.3390/v14020217 PMC 바로가기 [Article Type] Article
SBSA: an online service for somatic binding sequence annotationSBSA: 체세포 결합 시퀀스 주석을 위한 온라인 서비스Article Published on 2022-01-112022-09-11 Journal: Nucleic Acids Research [Category] 변종, 유전자 메커니즘, [키워드] alteration approach binding Cancer cells candidate cause demonstrated efficient ETS1 Genome genomic variant genomic variants help hypotheses identify joint mechanism miRNA molecular Mutation nucleotide offer online tool Organisms polymorphism promoter region Proteins reference genome RNA sequence sequences single nucleotide Single nucleotide polymorphism Somatic somatic mutation subjects Support TERT TFS therapeutic transcription factor transcription factors variants [DOI] 10.1093/nar/gkab877 PMC 바로가기 [Article Type] Article
Novel Nested-Seq Approach for SARS-CoV-2 Real-Time Epidemiology and In-Depth Mutational Profiling in WastewaterSARS-CoV-2 실시간 역학 및 폐수의 심층 돌연변이 프로파일링을 위한 새로운 Nested-Seq 접근 방식Article Published on 2021-08-072022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 변종, 진단, 치료기술, 치료제, [키워드] (RdRp 2019-nCoV Alpha variant amplification Analysis applied approach caused clinical sample clinical samples Combination COVID-19 D614G DNA sequencing effective Epidemiology Frequency genomic variants indicated lack Modification Molecular assay National nested PCR novel P323L pandemic PCR assays platform predicted Prevalence Profiling quantification RdRP Real-time monitoring Region regions reverse transcription RNA stability SARS-CoV-2 SARS-CoV-2 mutations SARS-CoV-2 NGS SARS-CoV-2 RNA SARS-CoV-2 sequencing SARS-CoV-2 variant SARS-CoV-2 variants sensitivity sequencing data sewage significantly Spike protein Treatment variant variants wastewater Wastewater-based epidemiology with COVID-19 [DOI] 10.3390/ijms22168498 PMC 바로가기 [Article Type] Article
RT-PCR based SARS-CoV-2 variant screening assays require careful quality controlRT-PCR 기반 SARS-CoV-2 변이체 스크리닝 분석에는 신중한 품질 관리가 필요합니다.Article Published on 2021-08-012022-09-11 Journal: Journal of Clinical Virology [Category] SARS, 변종, 치료기술, 치료제, [키워드] Accuracy antibody asked bioinformatic analysis characteristic complex confidence copy number detect determine diagnostic external quality assessment FIVE genetic information Genetic variations genomic variant genomic variants Genotype highest identify initial Interpretation Laboratory less lineages loss of confidence melting melting curve analysis molecular nucleotide nucleotide mutation nucleotide mutations participant pathogenicity qPCR Quality control reliability reported RT-PCR RT-qPCR SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant Sequencing Spike protein target region target regions the SARS-CoV-2 time-consuming Transmission variant Variant of concern. variants of concern Variation virus VoC whole genome Whole genome sequencing [DOI] 10.1016/j.jcv.2021.104905 PMC 바로가기 [Article Type] Article